The rookie first baseman finished 2 for 4, including his sixth home run of the season. Guzman started three games against the New York Yankees earlier this week and homered in each, but struck out as a pinch-hitter against the Royals on Thursday night.
Nomar Mazara also had a homer and three RBIs for Texas, which has won three of the first five games of a seven-game homestand.
Mike Minor (4-3) gave up home runs to Mike Moustakas and Jorge Soler, but earned the victory that ended Kansas Citys season-best three-game winning streak. Minor allowed four runs and seven hits in six innings. Keone Kela retired Salvador Perez on a flyout with the bases loaded for his 11th save in as many opportunities.
Royals lefty Eric Skoglund (1-5) allowed three home runs, all to left-handed batters. Shin-Soo Choo hit a solo homer in the first inning, Guzman gave the Rangers their first lead with a two-run shot in the fourth and Mazara added his 12th of the season in the fifth.
Moustakas had given the Royals a 2-0 lead in the top of the first with his 11th home run, a liner to right field.
Choo brought Texas within a run in the bottom of the inning with a line-drive homer into the corner of the right-center field bullpen.
The Rangers tied it in the third when Delino DeShields led off with a triple and scored as Mazara beat a double-play relay to first base on what would have been the third out.
Solers two-out solo homer in the top of the fourth restored Kansas Citys lead at 3-2.
With two outs in the bottom of the fourth, Guzman hit a two-run homer, a towering fly ball into the right-field seats, to put Texas ahead for the first time at 4-3.
Mazara added a two-run homer in the fifth for a 6-3 lead. His opposite-field fly ball bounced off the top of the wall just inside the left-field foul pole.
Ramon Torres doubled home the Royals fourth run in the seventh.
Texas added two runs in the eighth on Guzmans triple and a squeeze bunt by DeShields.
— FOX Sports Kansas City (@FSKansasCity) May 26, 2018
Royals: OF Alex Gordon missed his second straight game because of a sore hip and stiff neck. Manager Ned Yost said Gordon is day-to-day.
Rangers: Manager Jeff Banister said LHP Matt Moore, on the disabled list with a sore right knee, was OK after throwing in the bullpen Thursday. Hes scheduled to throw again Saturday and will be evaluated Sunday.
Royals: RHP Ian Kennedy (1-5, 5.30) will start Saturdays game at Texas.
Rangers: RHP Bartolo Colon (2-2, 3.51) will oppose KC two days after his 45th birthday. It will be his second attempt to tie Juan Marichal with 243 career wins, the most by a Dominican pitcher.